InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABI1

Summary

InnateDB Protein

IDBP-63999.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABI1

Protein Name

abl-interactor 1

Synonyms

ABI-1; ABLBP4; E3B1; NAP1BP; SSH3BP; SSH3BP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000365308

InnateDB Gene

IDBG-63979 (ABI1)

Protein Structure

UniProt Annotation

Function

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269PubMed:11003655, ECO:0000269PubMed:18328268}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23) with KMT2A/MLL1. ABI1 isoform 2 was found to be present in acute leukemia KMT2A/MLL1-ABI1 fusion transcript.

Tissue Specificity

Widely expressed, with highest expression in brain. {ECO:0000269PubMed:11418237}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	80 [view]
Protein-Protein	80 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0032403	protein complex binding

Biological Process

GO:0006928	cellular component movement
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008154	actin polymerization or depolymerization
GO:0008285	negative regulation of cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030426	growth cone
GO:0031209	SCAR complex
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome