Version 5.4
Homo sapiens Protein: NAPSA
Summary
InnateDB Protein IDBP-64306.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAPSA
Protein Name napsin A aspartic peptidase
Synonyms KAP; Kdap; NAP1; NAPA; SNAPA;
Species Homo sapiens
Ensembl Protein ENSP00000253719
InnateDB Gene IDBG-64304 (NAPSA)
Protein Structure
UniProt Annotation
Function May be involved in processing of pneumocyte surfactant precursors.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0033619 membrane protein proteolysis
GO:0043129 surfactant homeostasis
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
GO:0097208 alveolar lamellar body
Protein Structure and Domains
PDB ID
InterPro IPR001461 Aspartic peptidase
IPR021109 Aspartic peptidase domain
PFAM PF00026
PRINTS PR00792
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O96009
PhosphoSite PhosphoSite-O96009
TrEMBL
UniProt Splice Variant
Entrez Gene 9476
UniGene Hs.512843
RefSeq NP_004842
HUGO HGNC:13395
OMIM 605631
CCDS CCDS12794
HPRD 07064
IMGT
EMBL AF090386 AF098484 AF200345 BC017842
GenPept AAD04917 AAD13215 AAF17081 AAH17842

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca