InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCNT

Summary

InnateDB Protein

IDBP-6447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCNT

Protein Name

pericentrin

Synonyms

KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2; SCKL4;

Species

Homo sapiens

Ensembl Protein

ENSP00000352572

InnateDB Gene

IDBG-6445 (PCNT)

Protein Structure

UniProt Annotation

Function

Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269PubMed:10823944, ECO:0000269PubMed:11171385, ECO:0000269PubMed:18955030, ECO:0000269PubMed:20599736}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:10823944, ECO:0000269PubMed:11171385, ECO:0000269PubMed:18955030, ECO:0000269PubMed:22797915}. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.

Disease Associations

Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2) [MIM:210720]: Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence. {ECO:0000269PubMed:18157127, ECO:0000269PubMed:18174396}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in all tissues tested, including placenta, liver, kidney and thymus. {ECO:0000269PubMed:10823944}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0007051	spindle organization
GO:0021696	cerebellar cortex morphogenesis
GO:0021772	olfactory bulb development
GO:0035108	limb morphogenesis
GO:0035264	multicellular organism growth
GO:0042384	cilium assembly
GO:0043066	negative regulation of apoptotic process
GO:0048854	brain morphogenesis
GO:0061351	neural precursor cell proliferation
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0000242	pericentriolar material
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005814	centriole
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0031514	motile cilium
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body
GO:0045171	intercellular bridge