Version 5.4
Homo sapiens Protein: SPCS2
Summary
InnateDB Protein IDBP-64538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPCS2
Protein Name signal peptidase complex subunit 2 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263672
InnateDB Gene IDBG-64536 (SPCS2)
Protein Structure
UniProt Annotation
Function Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.
Subcellular Localization Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
Biological Process
GO:0006412 translation
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005787 signal peptidase complex
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR009582 Signal peptidase complex subunit 2
PFAM PF06703
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15005
PhosphoSite PhosphoSite-Q15005
TrEMBL
UniProt Splice Variant
Entrez Gene 9789
UniGene Hs.715758
RefSeq NP_055567
HUGO HGNC:28962
OMIM
CCDS CCDS44681
HPRD 15435
IMGT
EMBL BC008063 BC064957 BC070276 BC082231 BC106066 CR542233 CR542243 D14658 L38950
GenPept AAA60992 AAH08063 AAH64957 AAH70276 AAH82231 AAI06067 BAA03492 CAG47029 CAG47039

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca