InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RECK

Summary

InnateDB Protein

IDBP-64724.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RECK

Protein Name

reversion-inducing-cysteine-rich protein with kazal motifs

Synonyms

ST15;

Species

Homo sapiens

Ensembl Protein

ENSP00000367202

InnateDB Gene

IDBG-64722 (RECK)

Protein Structure

UniProt Annotation

Function

Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0001955	blood vessel maturation
GO:0007566	embryo implantation
GO:0010951	negative regulation of endopeptidase activity
GO:0030198	extracellular matrix organization