Version 5.4
Homo sapiens Protein: DCDC2
Summary
InnateDB Protein IDBP-64759.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCDC2
Protein Name doublecortin domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367711
InnateDB Gene IDBG-64753 (DCDC2)
Protein Structure
UniProt Annotation
Function May be involved in neuronal migration during development of the cerebral neocortex. {ECO:0000250}.
Subcellular Localization
Disease Associations Dyslexia 2 (DYX2) [MIM:600202]: A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. {ECO:0000269PubMed:16278297}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus. {ECO:0000269PubMed:10601354, ECO:0000269PubMed:16278297}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001764 neuron migration
GO:0006968 cellular defense response
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHG0
PhosphoSite PhosphoSite-Q9UHG0
TrEMBL
UniProt Splice Variant
Entrez Gene 51473
UniGene Hs.618980
RefSeq
HUGO HGNC:18141
OMIM 605755
CCDS
HPRD 09308
IMGT
EMBL AB032980 AF181720 AF181721 AL133043 AL359389 AL359713 BC050704 FO393410
GenPept AAF23610 AAF23612 AAH50704 BAA86468 CAB61371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca