Version 5.4
Homo sapiens Protein: KLK1
Summary
InnateDB Protein IDBP-64888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK1
Protein Name kallikrein 1
Synonyms hK1; Klk6; KLKR;
Species Homo sapiens
Ensembl Protein ENSP00000301420
InnateDB Gene IDBG-64886 (KLK1)
Protein Structure
UniProt Annotation
Function Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Subcellular Localization
Disease Associations
Tissue Specificity Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. {ECO:0000269PubMed:7749372}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06870
PhosphoSite PhosphoSite-
TrEMBL Q9UE84
UniProt Splice Variant
Entrez Gene 3816
UniGene Hs.738765
RefSeq NP_002248
HUGO HGNC:6357
OMIM 147910
CCDS CCDS12804
HPRD 01003
IMGT
EMBL AC010325 AF243527 AF277050 AY094609 AY703451 BC005313 BT007253 M12706 M25629 M33105 M33106 M33107 M33108 M33109 S77952 X13561
GenPept AAA36136 AAA59201 AAA59455 AAB34120 AAF86333 AAG33353 AAH05313 AAM11874 AAP35917 AAU12569 CAA31912

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca