InnateDB Protein
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IDBP-64997.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DGAT2
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Protein Name
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diacylglycerol O-acyltransferase 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365438
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InnateDB Gene
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IDBG-64993 (DGAT2)
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Protein Structure
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Function |
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:14521909}; Multi-pass membrane protein {ECO:0000269PubMed:14521909}. Lipid droplet {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. {ECO:0000269PubMed:11481335, ECO:0000269PubMed:14521909}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004144
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diacylglycerol O-acyltransferase activity
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GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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GO:0042803
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protein homodimerization activity
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GO:0050252
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retinol O-fatty-acyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007130
Diacylglycerol acyltransferase
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PFAM |
PF03982
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96PD7
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PhosphoSite |
PhosphoSite-Q96PD7
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TrEMBL |
S4R449
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UniProt Splice Variant |
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Entrez Gene |
84649
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UniGene |
Hs.730240
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RefSeq |
NP_001240820
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HUGO |
HGNC:16940
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OMIM |
606983
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CCDS |
CCDS58162
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HPRD |
07376
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IMGT |
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EMBL |
AB048286
AB073384
AF384161
AL834287
AP001922
AP003031
AY358532
AY780647
BC015234
CR749377
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GenPept |
AAH15234
AAK84176
AAQ88896
AAV35727
BAB40641
BAD38635
CAD38961
CAH18230
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