InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS9

Summary

InnateDB Protein

IDBP-65029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS9

Protein Name

regulator of G-protein signaling 9

Synonyms

PERRS; RGS9L;

Species

Homo sapiens

Ensembl Protein

ENSP00000262406

InnateDB Gene

IDBG-65027 (RGS9)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 3: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP. {ECO:0000250}.

Disease Associations

Prolonged electroretinal response suppression (PERRS) [MIM:608415]: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones. {ECO:0000269PubMed:14702087}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0032403	protein complex binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007399	nervous system development
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0043627	response to estrogen

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000342 Regulator of G protein signalling domain
IPR000591 DEP domain
IPR015898 G-protein gamma-like domain
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615
PF00610
PF00631

PRINTS

PR01301

PIRSF

SMART

SM00049
SM00224
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt