Version 5.4
Homo sapiens Protein: KLK4
Summary
InnateDB Protein IDBP-65134.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK4
Protein Name kallikrein-related peptidase 4
Synonyms AI2A1; ARM1; EMSP; EMSP1; kallikrein; KLK-L1; PRSS17; PSTS;
Species Homo sapiens
Ensembl Protein ENSP00000326159
InnateDB Gene IDBG-65132 (KLK4)
Protein Structure
UniProt Annotation
Function Involved in enamel formation. {ECO:0000269PubMed:15235027}.
Subcellular Localization Secreted.
Disease Associations Amelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1) [MIM:204700]: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. {ECO:0000269PubMed:15235027}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in prostate.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0030163 protein catabolic process
GO:0097186 amelogenesis
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5K2
PhosphoSite PhosphoSite-
TrEMBL Q96RU5
UniProt Splice Variant
Entrez Gene 9622
UniGene Hs.579933
RefSeq NP_004908
HUGO HGNC:6365
OMIM 603767
CCDS CCDS12809
HPRD 04793
IMGT
EMBL AC011483 AC037199 AF113140 AF113141 AF126401 AF135023 AF148532 AF228497 AF243527 AF259966 AF259967 AF259969 AF259971 BC069325 BC069403 BC069429 BC069489 BC096175 BC096176 BC096178
GenPept AAD21580 AAD21581 AAD26424 AAD38019 AAF70620 AAF81227 AAG33357 AAG43246 AAH69325 AAH69403 AAH69429 AAH69489 AAH96175 AAH96176 AAH96178 AAK71702 AAK71703 AAK71706 AAL14781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca