InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLK6

Summary

InnateDB Protein

IDBP-65232.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLK6

Protein Name

kallikrein-related peptidase 6

Synonyms

Bssp; hK6; Klk7; PRSS18; PRSS9; SP59;

Species

Homo sapiens

Ensembl Protein

ENSP00000366047

InnateDB Gene

IDBG-65226 (KLK6)

Protein Structure

UniProt Annotation

Function

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269PubMed:11983703, ECO:0000269PubMed:12878203, ECO:0000269PubMed:12928483, ECO:0000269PubMed:15557757, ECO:0000269PubMed:16321973, ECO:0000269PubMed:16987227}.

Subcellular Localization

Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.

Disease Associations

Tissue Specificity

In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. {ECO:0000269PubMed:10997858, ECO:0000269PubMed:11018688, ECO:0000269PubMed:11668196, ECO:0000269PubMed:12928483, ECO:0000269PubMed:16800739}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007417	central nervous system development
GO:0009611	response to wounding
GO:0010975	regulation of neuron projection development
GO:0016540	protein autoprocessing
GO:0030574	collagen catabolic process
GO:0042246	tissue regeneration
GO:0042445	hormone metabolic process
GO:0042552	myelination
GO:0042982	amyloid precursor protein metabolic process
GO:0045595	regulation of cell differentiation
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0070997	neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0015630	microtubule cytoskeleton
GO:0030141	secretory granule
GO:0031965	nuclear membrane
GO:0045171	intercellular bridge

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel

PFAM

PF00089
PF09342

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt