Version 5.4
Homo sapiens Protein: KPNA2
Summary
InnateDB Protein IDBP-65705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KPNA2
Protein Name karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Synonyms IPOA1; QIP2; RCH1; SRP1alpha;
Species Homo sapiens
Ensembl Protein ENSP00000332455
InnateDB Gene IDBG-65703 (KPNA2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
Experimentally validated
Total 174 [view]
Protein-Protein 174 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0008565 protein transporter activity
GO:0042826 histone deacetylase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000018 regulation of DNA recombination
GO:0000085 mitotic G2 phase
GO:0006259 DNA metabolic process
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000225 Armadillo
IPR002652 Importin-alpha, importin-beta-binding domain
IPR016024 Armadillo-type fold
PFAM PF00514
PF01749
PRINTS
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P52292
PhosphoSite PhosphoSite-P52292
TrEMBL J3QLL0
UniProt Splice Variant
Entrez Gene 3838
UniGene Hs.594238
RefSeq NP_002257
HUGO HGNC:6395
OMIM 600685
CCDS CCDS32713
HPRD 02818
IMGT
EMBL AC134407 AJ303086 BC005978 BC146905 BT006665 CH471099 U09559 U28386
GenPept AAA65700 AAA69957 AAH05978 AAI46906 AAP35311 CAC83080 EAW89041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca