Version 5.4
Homo sapiens Protein: NKG7
Summary
InnateDB Protein IDBP-65865.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKG7
Protein Name natural killer cell group 7 sequence
Synonyms GIG1; GMP-17; p15-TIA-1;
Species Homo sapiens
Ensembl Protein ENSP00000221978
InnateDB Gene IDBG-65863 (NKG7)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cell membrane {ECO:0000269PubMed:8570616}; Multi-pass membrane protein {ECO:0000269PubMed:8570616}. Cytoplasmic granule membrane {ECO:0000269PubMed:8570616}; Multi- pass membrane protein {ECO:0000269PubMed:8570616}. Note=Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils.
Disease Associations
Tissue Specificity Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta- expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B- cells, monocytes, and myeloid cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004031 PMP-22/EMP/MP20/Claudin superfamily
PFAM PF00822
PF13903
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16617
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 4818
UniGene
RefSeq NP_005592
HUGO HGNC:7830
OMIM 606008
CCDS CCDS12830
HPRD 16188
IMGT
EMBL AF305941 BC015759 S69115 U09608
GenPept AAA18209 AAB30078 AAG32329 AAH15759

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca