Version 5.4
| Homo sapiens Protein: LIM2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-65873.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | LIM2 | ||||||||
| Protein Name | lens intrinsic membrane protein 2, 19kDa | ||||||||
| Synonyms | CTRCT19; MP17; MP19; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000221973 | ||||||||
| InnateDB Gene | IDBG-65871 (LIM2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. | ||||||||
| Subcellular Localization | Membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | Cataract 19 (CTRCT19) [MIM:615277]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269PubMed:11917274}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||
| Tissue Specificity | Eye lens specific. {ECO:0000269PubMed:12107413}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR003935
Lens fibre membrane intrinsic protein IPR004031 PMP-22/EMP/MP20/Claudin superfamily IPR004032 PMP-22/EMP/MP20 |
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| PFAM |
PF00822
PF13903 |
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| PRINTS |
PR01457
PR01453 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P55344 | ||||||||
| PhosphoSite | PhosphoSite-P55344 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 3982 | ||||||||
| UniGene | Hs.162754 | ||||||||
| RefSeq | NP_085915 | ||||||||
| HUGO | HGNC:6610 | ||||||||
| OMIM | 154045 | ||||||||
| CCDS | CCDS12831 | ||||||||
| HPRD | 01097 | ||||||||
| IMGT | |||||||||
| EMBL | AF305941 AF340019 AF340020 BC069430 BC074916 BC074917 BC126139 CH471135 L04193 | ||||||||
| GenPept | AAG32328 AAH69430 AAH74916 AAH74917 AAI26140 AAK26327 AAK26328 EAW72010 | ||||||||