InnateDB Protein
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IDBP-65979.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GAB2
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Protein Name
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GRB2-associated binding protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354952
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InnateDB Gene
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IDBG-65975 (GAB2)
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Protein Structure
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Function |
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269PubMed:15750601, ECO:0000269PubMed:19172738}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:19172738}. Cell membrane {ECO:0000269PubMed:19172738}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
52
[view]
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Protein-Protein |
49
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005068
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transmembrane receptor protein tyrosine kinase adaptor activity
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GO:0005070
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SH3/SH2 adaptor activity
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GO:0005515
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protein binding
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GO:0005547
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phosphatidylinositol-3,4,5-trisphosphate binding
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GO:0043325
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phosphatidylinositol-3,4-bisphosphate binding
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Biological Process |
GO:0007169
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transmembrane receptor protein tyrosine kinase signaling pathway
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GO:0008284
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positive regulation of cell proliferation
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GO:0009967
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positive regulation of signal transduction
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GO:0030316
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osteoclast differentiation
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GO:0038095
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Fc-epsilon receptor signaling pathway
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GO:0043306
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positive regulation of mast cell degranulation
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GO:0045087
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innate immune response
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GO:0048015
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phosphatidylinositol-mediated signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UQC2
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PhosphoSite |
PhosphoSite-Q9UQC2
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TrEMBL |
E9PJE2
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UniProt Splice Variant |
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Entrez Gene |
9846
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UniGene |
Hs.695032
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RefSeq |
NP_536739
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HUGO |
HGNC:14458
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OMIM |
606203
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CCDS |
CCDS8259
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HPRD |
05866
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IMGT |
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EMBL |
AB011143
AB018413
AP002985
AP003086
BC131711
BC152459
CH471076
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GenPept |
AAI31712
AAI52460
BAA25497
BAA76737
EAW75057
EAW75058
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