InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ODZ4

Summary

InnateDB Protein

IDBP-66069.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ODZ4

Protein Name

odz, odd Oz/ten-m homolog 4 (Drosophila)

Synonyms

Doc4; ODZ4; Ten-M4; TNM4;

Species

Homo sapiens

Ensembl Protein

ENSP00000278550

InnateDB Gene

IDBG-66067 (ODZ4)

Protein Structure

UniProt Annotation

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small- diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0007165	signal transduction
GO:0031643	positive regulation of myelination
GO:0032289	central nervous system myelin formation
GO:0048666	neuron development
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0060038	cardiac muscle cell proliferation
GO:0060912	cardiac cell fate specification
GO:0097264	self proteolysis
GO:2000543	positive regulation of gastrulation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR006530 YD repeat
IPR008969 Carboxypeptidase-like, regulatory domain
IPR009471 Teneurin intracellular, N-terminal
IPR013111 EGF-like domain, extracellular
IPR022385 Rhs repeat-associated core

PFAM

PF00008
PF05593
PF06484
PF07974

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6N022