InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIST1H2BA

Summary

InnateDB Protein

IDBP-66292.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIST1H2BA

Protein Name

histone cluster 1, H2ba

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000274764

InnateDB Gene

IDBG-66290 (HIST1H2BA)

Protein Structure

UniProt Annotation

Function

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250, ECO:0000269PubMed:21249133}.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells. {ECO:0000269PubMed:12213818, ECO:0000269PubMed:21249133}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0006337	nucleosome disassembly
GO:0006954	inflammatory response
GO:0031639	plasminogen activation
GO:0035093	spermatogenesis, exchange of chromosomal proteins
GO:0051099	positive regulation of binding
GO:0071229	cellular response to acid
GO:0071674	mononuclear cell migration