InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC17A3

Summary

InnateDB Protein

IDBP-66492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC17A3

Protein Name

solute carrier family 17 (sodium phosphate), member 3

Synonyms

NPT4;

Species

Homo sapiens

Ensembl Protein

ENSP00000355307

InnateDB Gene

IDBG-66488 (SLC17A3)

Protein Structure

UniProt Annotation

Function

Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.

Subcellular Localization

Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein.Isoform 2: Cell membrane {ECO:0000269PubMed:20810651}; Multi-pass membrane protein {ECO:0000269PubMed:20810651}.

Disease Associations

Tissue Specificity

Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level). {ECO:0000269PubMed:20810651, ECO:0000269PubMed:9149941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005436	sodium:phosphate symporter activity
GO:0008308	voltage-gated anion channel activity
GO:0008514	organic anion transmembrane transporter activity
GO:0015143	urate transmembrane transporter activity
GO:0015238	drug transmembrane transporter activity
GO:0015562	efflux transmembrane transporter activity
GO:0019534	toxin transporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0006817	phosphate ion transport
GO:0006855	drug transmembrane transport
GO:0015711	organic anion transport
GO:0015747	urate transport
GO:0015760	glucose-6-phosphate transport
GO:0015849	organic acid transport
GO:0015893	drug transport
GO:0034220	ion transmembrane transport
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0046415	urate metabolic process
GO:0055085	transmembrane transport
GO:1901998	toxin transport

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR017373 Sodium-dependent phosphate transport protein 4 , predicted
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

PIRSF038072

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00476