Version 5.4
Homo sapiens Protein: IL36G
Summary
InnateDB Protein IDBP-66662.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL36G
Protein Name interleukin 36, gamma
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365672
InnateDB Gene IDBG-66658 (IL36G)
Protein Structure
UniProt Annotation
Function Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005149 interleukin-1 receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000975 Interleukin-1 family
IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
IPR008996 Cytokine, IL-1-like
PFAM PF00340
PRINTS PR00264
PR01360
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZH8
PhosphoSite PhosphoSite-Q9NZH8
TrEMBL
UniProt Splice Variant
Entrez Gene 56300
UniGene Hs.211238
RefSeq NP_001265497
HUGO HGNC:15741
OMIM 605542
CCDS CCDS62992
HPRD 05707
IMGT
EMBL AC016724 AF200492 AF206696 AY359111 AY968311 BC096721 BC098130 BC098155 BC098337 BN000002
GenPept AAF69248 AAG35670 AAH96721 AAH98130 AAH98155 AAH98337 AAQ89469 AAX59035 AAY14987 CAD29874

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca