Version 5.4
Homo sapiens Protein: IL36A
Summary
InnateDB Protein IDBP-66691.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL36A
Protein Name interleukin 36, alpha
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000259211
InnateDB Gene IDBG-66689 (IL36A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0032755 positive regulation of interleukin-6 production
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000975 Interleukin-1 family
IPR003294 Interleukin-1 alpha/beta
IPR008996 Cytokine, IL-1-like
PFAM PF00340
PRINTS PR00264
PR01357
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHA7
PhosphoSite PhosphoSite-Q9UHA7
TrEMBL
UniProt Splice Variant
Entrez Gene 27179
UniGene Hs.278910
RefSeq NP_055255
HUGO HGNC:15562
OMIM 605509
CCDS CCDS42734
HPRD 16113
IMGT
EMBL AC016724 AF201831 AK314149 AY944686 BC107042 BC107043 BN000002
GenPept AAF25211 AAI07043 AAI07044 AAX20113 AAY14988 BAG36836 CAD29875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca