InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2R1A

Summary

InnateDB Protein

IDBP-66702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R1A

Protein Name

protein phosphatase 2, regulatory subunit A, alpha

Synonyms

PP2A-Aalpha; PP2AAALPHA; PR65A;

Species

Homo sapiens

Ensembl Protein

ENSP00000324804

InnateDB Gene

IDBG-66700 (PPP2R1A)

Protein Structure

UniProt Annotation

Function

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis. {ECO:0000269PubMed:16580887}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Chromosome, centromere {ECO:0000269PubMed:16580887}. Note=Centromeric localization requires the presence of BUB1.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 228 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	228 [view]
Protein-Protein	227 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0004722	protein serine/threonine phosphatase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188	inactivation of MAPK activity
GO:0000278	mitotic cell cycle
GO:0006275	regulation of DNA replication
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0006470	protein dephosphorylation
GO:0006672	ceramide metabolic process
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007084	mitotic nuclear envelope reassembly
GO:0008380	RNA splicing
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010033	response to organic substance
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019932	second-messenger-mediated signaling
GO:0030111	regulation of Wnt signaling pathway
GO:0030155	regulation of cell adhesion
GO:0030308	negative regulation of cell growth
GO:0040008	regulation of growth
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595	regulation of cell differentiation
GO:0070262	peptidyl-serine dephosphorylation
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane