InnateDB Protein
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IDBP-67070.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCNB3
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Protein Name
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cyclin B3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365210
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InnateDB Gene
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IDBG-67068 (CCNB3)
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Protein Structure
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Function |
Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. {ECO:0000269PubMed:12185076}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12185076}.
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Disease Associations |
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Tissue Specificity |
Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues. {ECO:0000269PubMed:11846420, ECO:0000269PubMed:12185076}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000079
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regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0007126
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meiotic nuclear division
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GO:0010389
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regulation of G2/M transition of mitotic cell cycle
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Cellular Component |
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PDB ID |
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InterPro |
IPR004367
Cyclin, C-terminal domain
IPR006671
Cyclin, N-terminal
IPR013763
Cyclin-like
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PFAM |
PF02984
PF00134
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PRINTS |
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PIRSF |
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WWL7
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PhosphoSite |
PhosphoSite-Q8WWL7
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TrEMBL |
Q8WTR6
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UniProt Splice Variant |
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Entrez Gene |
85417
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UniGene |
Hs.740165
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RefSeq |
XP_006724673
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HUGO |
HGNC:18709
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OMIM |
300456
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CCDS |
CCDS14331
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HPRD |
02350
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IMGT |
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EMBL |
AJ314764
AJ314765
AJ314766
AJ416458
AJ421672
AJ421673
AJ421674
AL137550
AL591367
BX323840
CH471180
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GenPept |
CAB70806
CAC40024
CAC40025
CAC40026
CAC94915
CAD18845
CAD18846
CAD18847
CAI41320
CAI41321
CAI43220
CAI43221
EAW89922
EAW89923
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