InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNB3

Summary

InnateDB Protein

IDBP-67078.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNB3

Protein Name

cyclin B3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000338682

InnateDB Gene

IDBG-67068 (CCNB3)

Protein Structure

UniProt Annotation

Function

Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. {ECO:0000269PubMed:12185076}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12185076}.

Disease Associations

Tissue Specificity

Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues. {ECO:0000269PubMed:11846420, ECO:0000269PubMed:12185076}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007126	meiotic nuclear division
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0051726	regulation of cell cycle