Version 5.4
Homo sapiens Protein: BMP15
Summary
InnateDB Protein IDBP-67315.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP15
Protein Name bone morphogenetic protein 15
Synonyms GDF9B; ODG2; POF4;
Species Homo sapiens
Ensembl Protein ENSP00000252677
InnateDB Gene IDBG-67313 (BMP15)
Protein Structure
UniProt Annotation
Function May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. {ECO:0000269PubMed:18227435}.
Subcellular Localization Secreted.
Disease Associations Ovarian dysgenesis 2 (ODG2) [MIM:300510]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. {ECO:0000269PubMed:15136966}. Note=The disease is caused by mutations affecting the gene represented in this entry.Premature ovarian failure 4 (POF4) [MIM:300510]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269PubMed:16464940, ECO:0000269PubMed:16508750, ECO:0000269PubMed:16645022, ECO:0000269PubMed:19263482, ECO:0000269PubMed:19438907}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008083 growth factor activity
Biological Process
GO:0001541 ovarian follicle development
GO:0007292 female gamete generation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060016 granulosa cell development
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine
PFAM PF00019
PRINTS PR00669
PIRSF
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95972
PhosphoSite PhosphoSite-O95972
TrEMBL
UniProt Splice Variant
Entrez Gene 9210
UniGene Hs.532692
RefSeq NP_005439
HUGO HGNC:1068
OMIM 300247
CCDS CCDS14334
HPRD 02216
IMGT
EMBL AF082349 AF082350 AJ132405 AL359914 BC069155 BC117264 BC117266
GenPept AAC99768 AAH69155 AAI17265 AAI17267 CAB43531 CAI41226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca