InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRIN2C

Summary

InnateDB Protein

IDBP-67635.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIN2C

Protein Name

glutamate receptor, ionotropic, N-methyl D-aspartate 2C

Synonyms

GluN2C; NMDAR2C; NR2C;

Species

Homo sapiens

Ensembl Protein

ENSP00000293190

InnateDB Gene

IDBG-67631 (GRIN2C)

Protein Structure

UniProt Annotation

Function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006810	transport
GO:0006812	cation transport
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0008104	protein localization
GO:0009611	response to wounding
GO:0033058	directional locomotion
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042177	negative regulation of protein catabolic process
GO:0042391	regulation of membrane potential
GO:0050885	neuromuscular process controlling balance
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10565
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt