InnateDB Protein
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IDBP-68024.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ASIP
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Protein Name
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agouti signaling protein
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Synonyms
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AGSW; AGTI; AGTIL; ASP; SHEP9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364092
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InnateDB Gene
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IDBG-68022 (ASIP)
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Protein Structure
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Function |
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007733
Agouti
IPR027300
Agouti domain
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PFAM |
PF05039
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PRINTS |
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PIRSF |
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SMART |
SM00792
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TIGRFAMs |
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Modification |
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SwissProt |
P42127
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PhosphoSite |
PhosphoSite-P42127
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
434
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UniGene |
Hs.659995
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RefSeq |
NP_001663
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HUGO |
HGNC:745
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OMIM |
600201
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CCDS |
CCDS13232
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HPRD |
02562
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IMGT |
|
EMBL |
AL035458
BC104238
BC104239
L37019
U12770
U12774
U12775
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GenPept |
AAA89208
AAB61247
AAI04239
AAI04240
CAB96679
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