Version 5.4
Bos taurus Protein: IL10
Summary
InnateDB Protein IDBP-680552.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL10
Protein Name interleukin-10 precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008793
InnateDB Gene IDBG-629159 (IL10)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0002237 response to molecule of bacterial origin
GO:0002740 negative regulation of cytokine secretion involved in immune response
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus
GO:0002904 positive regulation of B cell apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0010468 regulation of gene expression
GO:0030886 negative regulation of myeloid dendritic cell activation
GO:0030889 negative regulation of B cell proliferation
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032800 receptor biosynthetic process
GO:0042742 defense response to bacterium
GO:0044130 negative regulation of growth of symbiont in host
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050715 positive regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0060670 branching involved in labyrinthine layer morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000098 Interleukin-10
IPR009079 Four-helical cytokine-like, core
IPR020443 Interleukin-10/19/20/24/26 family
PFAM PF00726
PRINTS PR01294
PIRSF
SMART SM00188
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MCS4
UniProt Splice Variant
Entrez Gene 281246
UniGene
RefSeq NP_776513
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02041972
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca