InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MAP1LC3B

Summary

InnateDB Protein

IDBP-681671.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP1LC3B

Protein Name

Microtubule-associated proteins 1A/1B light chain 3B

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015449

InnateDB Gene

IDBG-630234 (MAP1LC3B)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.

Predicted by orthology
Total	100 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006914	autophagy

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005930	axoneme
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0031090	organelle membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR004241 Autophagy protein Atg8 ubiquitin like
IPR007242 Ubiquitin-like protein Atg12
IPR029071 Ubiquitin-related domain

PFAM

PF02991
PF04110

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O41515

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

408001

UniGene

Bt.88486

RefSeq

NP_001001169

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY570553 BC102891 U80885

GenPept

AAB72082 AAI02892 AAS78585