InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPB41L5

Summary

InnateDB Protein

IDBP-68170.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPB41L5

Protein Name

erythrocyte membrane protein band 4.1 like 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000329687

InnateDB Gene

IDBG-68166 (EPB41L5)

Protein Structure

UniProt Annotation

Function

May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269PubMed:17920587}.

Subcellular Localization

Cytoplasm. Cell junction, adherens junction. Note=Associated with the plasma membrane. Colocalizes with CTNNB1, an adherens junction marker (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008092	cytoskeletal protein binding

Biological Process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0019898	extrinsic component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF08736
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt