Version 5.4
Bos taurus Protein: GABPA
Summary
InnateDB Protein IDBP-681756.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABPA
Protein Name GA-binding protein alpha chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025345
InnateDB Gene IDBG-630306 (GABPA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000418 Ets domain
IPR003118 Pointed domain
IPR013761 Sterile alpha motif/pointed domain
IPR016312 Transcription factor, GA-binding, alpha subunit
IPR024668 GA-binding protein alpha subunit, N-terminal
IPR029071 Ubiquitin-related domain
PFAM PF00178
PF02198
PF11620
PRINTS PR00454
PIRSF PIRSF001703
SMART SM00413
SM00251
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q0VC98
UniProt Splice Variant
Entrez Gene 510204
UniGene Bt.47174
RefSeq NP_001068905
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120283 DAAA02000241 DAAA02000242
GenPept AAI20284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca