InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDXP

Summary

InnateDB Protein

IDBP-6837.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDXP

Protein Name

pyridoxal (pyridoxine, vitamin B6) phosphatase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000215904

InnateDB Gene

IDBG-402197 (PDXP)

Protein Structure

UniProt Annotation

Function

Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. {ECO:0000269PubMed:14522954, ECO:0000269PubMed:15580268}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269PubMed:15580268}; Peripheral membrane protein {ECO:0000269PubMed:15580268}; Cytoplasmic side {ECO:0000269PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269PubMed:15580268}; Peripheral membrane protein {ECO:0000269PubMed:15580268}; Cytoplasmic side {ECO:0000269PubMed:15580268}. Cell membrane {ECO:0000269PubMed:15580268}; Peripheral membrane protein {ECO:0000269PubMed:15580268}; Cytoplasmic side {ECO:0000269PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. {ECO:0000269PubMed:14522954, ECO:0000269PubMed:15580268}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004647	phosphoserine phosphatase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0031072	heat shock protein binding
GO:0033883	pyridoxal phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007088	regulation of mitosis
GO:0008152	metabolic process
GO:0030836	positive regulation of actin filament depolymerization
GO:0031247	actin rod assembly
GO:0032361	pyridoxal phosphate catabolic process
GO:0032465	regulation of cytokinesis
GO:0071318	cellular response to ATP

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0030496	midbody
GO:0031258	lamellipodium membrane
GO:0032154	cleavage furrow
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome
GO:0070938	contractile ring