Version 5.4
Bos taurus Protein: SLC6A8
Summary
InnateDB Protein IDBP-683937.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A8
Protein Name Sodium- and chloride-dependent creatine transporter 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013141
InnateDB Gene IDBG-632317 (SLC6A8)
Protein Structure
UniProt Annotation
Function Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005309 creatine:sodium symporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006836 neurotransmitter transport
GO:0055085 transmembrane transport
GO:1902598 creatine transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR002984 Sodium:neurotransmitter symporter, creatine
PFAM PF00209
PRINTS PR00176
PR01199
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O18875
PhosphoSite PhosphoSite-
TrEMBL F1MTW1
UniProt Splice Variant
Entrez Gene 282367
UniGene Bt.88817
RefSeq NP_777036
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF027197 DAAA02070077 DAAA02070078
GenPept AAB84029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca