Version 5.4
Bos taurus Protein: C16H1orf187
Summary
InnateDB Protein IDBP-684304.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C16H1orf187
Protein Name Draxin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019092
InnateDB Gene IDBG-632674 (C16H1orf187)
Protein Structure
UniProt Annotation
Function Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255HAMAP- Rule:MF_03060}.
Subcellular Localization Secreted {ECO:0000255HAMAP-Rule:MF_03060}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0016055 Wnt signaling pathway
GO:0021516 dorsal spinal cord development
GO:0021528 commissural neuron differentiation in spinal cord
GO:0030517 negative regulation of axon extension
GO:0030900 forebrain development
GO:0043524 negative regulation of neuron apoptotic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0C8S2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506110
UniGene Bt.62133
RefSeq NP_001181941
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03122053 AAFC03122054
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca