Version 5.4
| Bos taurus Protein: PLA1A | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-684414.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | PLA1A | ||||||||
| Protein Name | Phospholipase A1 member A | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000012361 | ||||||||
| InnateDB Gene | IDBG-632764 (PLA1A) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted {ECO:0000305}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000734
Lipase IPR013818 Lipase, N-terminal IPR016272 Lipoprotein lipase, LIPH IPR029058 Alpha/Beta hydrolase fold |
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| PFAM |
PF00151
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| PRINTS |
PR00821
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| PIRSF |
PIRSF000865
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| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q5E9H0 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 515900 | ||||||||
| UniGene | Bt.20385 | ||||||||
| RefSeq | NP_001015610 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC112606 BT020950 | ||||||||
| GenPept | AAI12607 AAX08967 | ||||||||