InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUDT1

Summary

InnateDB Protein

IDBP-6847.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT1

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 1

Synonyms

MTH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000339503

InnateDB Gene

IDBG-6841 (NUDT1)

Protein Structure

UniProt Annotation

Function

Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269PubMed:10373420, ECO:0000269PubMed:10608900, ECO:0000269PubMed:11139615, ECO:0000269PubMed:12857738, ECO:0000269PubMed:22556419}.

Subcellular Localization

Isoform p18: Cytoplasm. Mitochondrion matrix. Nucleus. Note=Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.Isoform p26: Cytoplasm. Mitochondrion matrix.

Disease Associations

Tissue Specificity

Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. {ECO:0000269PubMed:9211940}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0030515	snoRNA binding
GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0046872	metal ion binding
GO:0047693	ATP diphosphatase activity

Biological Process

GO:0006184	GTP catabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006200	ATP catabolic process
GO:0006203	dGTP catabolic process
GO:0006281	DNA repair
GO:0006979	response to oxidative stress
GO:0034656	nucleobase-containing small molecule catabolic process
GO:0042262	DNA protection
GO:0044281	small molecule metabolic process
GO:0046061	dATP catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process