Version 5.4
Homo sapiens Protein: GYPC
Summary
InnateDB Protein IDBP-68660.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GYPC
Protein Name glycophorin C (Gerbich blood group)
Synonyms CD236; CD236R; GE; GPC; GPD; GYPD; PAS-2; PAS-2\';
Species Homo sapiens
Ensembl Protein ENSP00000259254
InnateDB Gene IDBG-68658 (GYPC)
Protein Structure
UniProt Annotation
Function This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Subcellular Localization Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.
Disease Associations
Tissue Specificity Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed. {ECO:0000269PubMed:2349119}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR003585 Neurexin/syndecan/glycophorin C
PFAM
PRINTS
PIRSF
SMART SM00294
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04921
PhosphoSite PhosphoSite-P04921
TrEMBL A8D444
UniProt Splice Variant
Entrez Gene 2995
UniGene Hs.59138
RefSeq NP_002092
HUGO HGNC:4704
OMIM 110750
CCDS CCDS2136
HPRD 00193
IMGT
EMBL AC013474 AK312032 AY838876 BC104246 BC104247 BC106051 EU137141 EU137142 EU137143 M11802 M28335 M29662 M36284 X12496 X13890 X13892 X13893 X14242 X51973
GenPept AAA52574 AAA52625 AAA52626 AAA60023 AAI04247 AAI04248 AAI06052 AAV80423 AAY14660 ABV55110 ABV55111 ABV55112 BAG34969 CAA31016 CAA32093 CAA32458 CAA36235

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca