InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCOA6

Summary

InnateDB Protein

IDBP-68728.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOA6

Protein Name

nuclear receptor coactivator 6

Synonyms

AIB3; ASC2; NRC; PRIP; RAP250; TRBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000363929

InnateDB Gene

IDBG-68724 (NCOA6)

Protein Structure

UniProt Annotation

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	118 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0046965	retinoid X receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006352	DNA-templated transcription, initiation
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0007420	brain development
GO:0007507	heart development
GO:0009725	response to hormone
GO:0030099	myeloid cell differentiation
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0042921	glucocorticoid receptor signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0035097	histone methyltransferase complex
GO:0043231	intracellular membrane-bounded organelle