Version 5.4
Bos taurus Protein: MYH10
Summary
InnateDB Protein IDBP-687823.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH10
Protein Name Myosin-10
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028188
InnateDB Gene IDBG-635933 (MYH10)
Protein Structure
UniProt Annotation
Function Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). {ECO:0000250}.
Subcellular Localization Cell projection, lamellipodium {ECO:0000250}. Note=Colocalizes with MCC at the leading edge of migrating cells. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0030898 actin-dependent ATPase activity
GO:0043531 ADP binding
GO:0051015 actin filament binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001778 plasma membrane repair
GO:0006200 ATP catabolic process
GO:0006887 exocytosis
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007097 nuclear migration
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007512 adult heart development
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0008360 regulation of cell shape
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021680 cerebellar Purkinje cell layer development
GO:0030036 actin cytoskeleton organization
GO:0030048 actin filament-based movement
GO:0030239 myofibril assembly
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0050885 neuromuscular process controlling balance
GO:0055003 cardiac myofibril assembly
GO:0055015 ventricular cardiac muscle cell development
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0031594 neuromuscular junction
GO:0032154 cleavage furrow
GO:0042641 actomyosin
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0097513 myosin II filament
Protein Structure and Domains
PDB ID
InterPro IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR008989 Myosin S1 fragment, N-terminal
IPR009053 Prefoldin
IPR011072 HR1 rho-binding repeat
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00612
PF00063
PF01576
PF02736
PF02185
PRINTS PR00193
PIRSF
SMART SM00015
SM00242
SM00742
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q27991
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 317655
UniGene Bt.4057
RefSeq NP_777259
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB022023 U15716
GenPept AAA87715 BAA36494

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca