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InnateDB Protein
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IDBP-687938.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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XBP1
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Protein Name
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X-box-binding protein 1
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Synonyms
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XBPP1;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000007835
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InnateDB Gene
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IDBG-636048 (XBP1)
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Protein Structure
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| Function |
Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
18 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0001085
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RNA polymerase II transcription factor binding
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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| Biological Process |
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GO:0002070
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epithelial cell maturation
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0031017
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exocrine pancreas development
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GO:0042593
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glucose homeostasis
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0060691
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epithelial cell maturation involved in salivary gland development
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GO:1900103
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positive regulation of endoplasmic reticulum unfolded protein response
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GO:1901800
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positive regulation of proteasomal protein catabolic process
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR004827
Basic-leucine zipper domain
IPR008917
Transcription factor, Skn-1-like, DNA-binding domain
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| PFAM |
PF00170
PF07716
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| PRINTS |
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| PIRSF |
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| SMART |
SM00338
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q3SZZ2
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
541236
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| UniGene |
Bt.89117
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| RefSeq |
NP_001029899
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC102639
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| GenPept |
AAI02640
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Version 5.4