InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GLUL

Summary

InnateDB Protein

IDBP-688996.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLUL

Protein Name

Glutamine synthetase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000038301

InnateDB Gene

IDBG-637016 (GLUL)

Protein Structure

UniProt Annotation

Function

Essential for proliferation of fetal skin fibroblasts. This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004351	glutamate decarboxylase activity
GO:0004356	glutamate-ammonia ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016829	lyase activity
GO:0016874	ligase activity
GO:0042802	identical protein binding

Biological Process

GO:0006542	glutamine biosynthetic process
GO:0006807	nitrogen compound metabolic process
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0009267	cellular response to starvation
GO:0009749	response to glucose

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome
GO:0097386	glial cell projection