Version 5.4
Bos taurus Protein: FAS
Summary
InnateDB Protein IDBP-689361.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAS
Protein Name Tumor necrosis factor receptor superfamily member 6
Synonyms APO1; TNFRSF6;
Species Bos taurus
Ensembl Protein ENSBTAP00000014282
InnateDB Gene IDBG-637356 (FAS)
Protein Structure
UniProt Annotation
Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0002377 immunoglobulin production
GO:0003014 renal system process
GO:0006915 apoptotic process
GO:0006924 activation-induced cell death of T cells
GO:0006925 inflammatory cell apoptotic process
GO:0006927 transformed cell apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009636 response to toxic substance
GO:0010467 gene expression
GO:0019724 B cell mediated immunity
GO:0032464 positive regulation of protein homooligomerization
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045060 negative thymic T cell selection
GO:0045619 regulation of lymphocyte differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0048536 spleen development
GO:0050869 negative regulation of B cell activation
GO:0051260 protein homooligomerization
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0071285 cellular response to lithium ion
GO:0071455 cellular response to hyperoxia
GO:0097049 motor neuron apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097527 necroptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000488 Death domain
IPR001368 TNFR/NGFR cysteine-rich region
IPR008063 Fas receptor
IPR011029 Death-like domain
PFAM PF00531
PF00020
PRINTS PR01680
PIRSF
SMART SM00005
SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51867
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282488
UniGene Bt.4345
RefSeq NP_777087
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U34794
GenPept AAC48546

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca