Version 5.4
Homo sapiens Protein: KIR2DL1
Summary
InnateDB Protein IDBP-68941.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIR2DL1
Protein Name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
Synonyms CD158A; KIR-K64; KIR221; NKAT; NKAT-1; NKAT1; p58.1;
Species Homo sapiens
Ensembl Protein ENSP00000336769
InnateDB Gene IDBG-68931 (KIR2DL1)
Protein Structure
UniProt Annotation
Function Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269PubMed:18604210}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0002769 natural killer cell inhibitory signaling pathway
GO:0006955 immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR013151 Immunoglobulin
PFAM PF00047
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43626
PhosphoSite PhosphoSite-P43626
TrEMBL Q6H2H4
UniProt Splice Variant
Entrez Gene 3802
UniGene
RefSeq NP_055033
HUGO HGNC:6329
OMIM 604936
CCDS CCDS12904
HPRD 12000
IMGT
EMBL AF022045 AY366237 AY366238 AY366239 AY789055 AY789056 JX008027 JX008029 JX008031 L41267 U24076 U24078
GenPept AAA69868 AAB95318 AAC50335 AAC50337 AAR16195 AAR16196 AAR16197 AAX23100 AAX23101 AFV74752 AFV74759 AFV74770

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca