Version 5.4
Bos taurus Protein: ANKRD1
Summary
InnateDB Protein IDBP-689482.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKRD1
Protein Name Ankyrin repeat domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015584
InnateDB Gene IDBG-637468 (ANKRD1)
Protein Structure
UniProt Annotation
Function May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0031432 titin binding
GO:0042826 histone deacetylase binding
GO:0070412 R-SMAD binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0035690 cellular response to drug
GO:0035914 skeletal muscle cell differentiation
GO:0035994 response to muscle stretch
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050714 positive regulation of protein secretion
GO:0055008 cardiac muscle tissue morphogenesis
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030016 myofibril
GO:0031674 I band
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBX7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510376
UniGene Bt.49329
RefSeq NP_001029550
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103045
GenPept AAI03046

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca