InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GEN1

Summary

InnateDB Protein

IDBP-689755.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GEN1

Protein Name

Gen homolog 1, endonuclease (Drosophila)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000041132

InnateDB Gene

IDBG-637719 (GEN1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0008821	crossover junction endodeoxyribonuclease activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0010824	regulation of centrosome duplication
GO:0071139	resolution of recombination intermediates
GO:0071140	resolution of mitotic recombination intermediates
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005813	centrosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006085 XPG N-terminal
IPR006086 XPG-I domain
IPR008918 Helix-hairpin-helix motif, class 2
IPR020045 5\'-3\' exonuclease, C-terminal domain
IPR029060 PIN domain-like

PFAM

PF00752
PF00867
PF01367
PF09293

PRINTS

PIRSF

SMART

SM00485
SM00484
SM00279

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite