InnateDB Protein
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IDBP-69050.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PIP5K1B
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Protein Name
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phosphatidylinositol-4-phosphate 5-kinase, type I, beta
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Synonyms
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MSS4; STM7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000265382
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InnateDB Gene
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IDBG-69048 (PIP5K1B)
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Protein Structure
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Function |
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. {ECO:0000269PubMed:8955136}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002498
Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034
Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
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PFAM |
PF01504
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PRINTS |
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PIRSF |
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SMART |
SM00330
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TIGRFAMs |
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Modification |
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SwissProt |
O14986
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PhosphoSite |
PhosphoSite-O14986
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TrEMBL |
Q7KYT6
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UniProt Splice Variant |
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Entrez Gene |
8395
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UniGene |
Hs.534371
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RefSeq |
NP_003549
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HUGO |
HGNC:8995
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OMIM |
602745
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CCDS |
CCDS6624
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HPRD |
04121
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IMGT |
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EMBL |
AK292734
AK295587
AL162730
AL354794
AL356219
BC030587
CH471089
U52376
U52377
U52378
U52379
U52380
U52381
U52382
U52383
U52384
U52385
U52386
U52387
U78579
U78580
U78581
X92493
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GenPept |
AAC50914
AAC50915
AAC50916
AAC51327
AAH30587
BAF85423
BAG58479
CAA63224
CAH71831
CAI12622
CAI12623
CAI12624
CAI12625
CAI14092
CAI14093
CAI14094
CAI14095
EAW62465
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