Version 5.4
Homo sapiens Protein: IWS1
Summary
InnateDB Protein IDBP-69123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IWS1
Protein Name IWS1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295321
InnateDB Gene IDBG-69121 (IWS1)
Protein Structure
UniProt Annotation
Function Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269PubMed:17184735, ECO:0000269PubMed:17234882, ECO:0000269PubMed:19141475}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00649, ECO:0000269PubMed:17184735, ECO:0000269PubMed:17234882}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010793 regulation of mRNA export from nucleus
GO:0050684 regulation of mRNA processing
GO:0051028 mRNA transport
GO:0090239 regulation of histone H4 acetylation
GO:2001253 regulation of histone H3-K36 trimethylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR017923 Transcription factor IIS, N-terminal
PFAM PF08711
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96ST2
PhosphoSite PhosphoSite-Q96ST2
TrEMBL
UniProt Splice Variant
Entrez Gene 55677
UniGene Hs.469879
RefSeq NP_060439
HUGO HGNC:25467
OMIM
CCDS CCDS2146
HPRD 07639
IMGT
EMBL AK000868 AK001717 AK027561 AK056881 AL834178 BC065279 BC110536 BC110537
GenPept AAH65279 AAI10537 AAI10538 BAA91402 BAA91858 BAB55198 BAB71301 CAD38875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca