InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYH7B

Summary

InnateDB Protein

IDBP-69154.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH7B

Protein Name

myosin, heavy chain 7B, cardiac muscle, beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262873

InnateDB Gene

IDBG-69150 (MYH7B)

Protein Structure

UniProt Annotation

Function

Involved in muscle contraction. {ECO:0000269PubMed:11919279}.

Subcellular Localization

Membrane {ECO:0000269PubMed:15755502}; Peripheral membrane protein {ECO:0000269PubMed:15755502}.

Disease Associations

Tissue Specificity

Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver. {ECO:0000269PubMed:10819331}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0051015	actin filament binding

Biological Process

GO:0008152	metabolic process
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0016020	membrane
GO:0016459	myosin complex
GO:0032982	myosin filament

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR008989 Myosin S1 fragment, N-terminal
IPR009053 Prefoldin
IPR010978 tRNA-binding arm
IPR010989 t-SNARE
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01576
PF02736

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt