InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRP68

Summary

InnateDB Protein

IDBP-69302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRP68

Protein Name

signal recognition particle 68kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000312066

InnateDB Gene

IDBG-69300 (SRP68)

Protein Structure

UniProt Annotation

Function

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	27 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005047	signal recognition particle binding
GO:0008312	7S RNA binding
GO:0030942	endoplasmic reticulum signal peptide binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0042493	response to drug
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005783	endoplasmic reticulum
GO:0005786	signal recognition particle, endoplasmic reticulum targeting
GO:0005829	cytosol
GO:0005840	ribosome