InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LGALS1

Summary

InnateDB Protein

IDBP-6931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGALS1

Protein Name

lectin, galactoside-binding, soluble, 1

Synonyms

GAL1; GBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000215909

InnateDB Gene

IDBG-6929 (LGALS1)

Protein Structure

UniProt Annotation

Function

May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. {ECO:0000269PubMed:14617626, ECO:0000269PubMed:18796645, ECO:0000269PubMed:19497882}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:14617626}.

Disease Associations

Tissue Specificity

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. {ECO:0000269PubMed:18824694, ECO:0000269PubMed:19497882}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.

Experimentally validated
Total	59 [view]
Protein-Protein	57 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016936	galactoside binding
GO:0030246	carbohydrate binding
GO:0030395	lactose binding
GO:0042803	protein homodimerization activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002317	plasma cell differentiation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0010812	negative regulation of cell-substrate adhesion
GO:0010977	negative regulation of neuron projection development
GO:0031295	T cell costimulation
GO:0033555	multicellular organismal response to stress
GO:0034120	positive regulation of erythrocyte aggregation
GO:0042493	response to drug
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045445	myoblast differentiation
GO:0048678	response to axon injury
GO:0071333	cellular response to glucose stimulus
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome