Version 5.4
Homo sapiens Protein: SAP130
Summary
InnateDB Protein IDBP-69378.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAP130
Protein Name Sin3A-associated protein, 130kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000350333
InnateDB Gene IDBG-69376 (SAP130)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269PubMed:12724404}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15561718}.
Disease Associations
Tissue Specificity Expressed in various cancer cell ines. {ECO:0000269PubMed:12724404}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0043966 histone H3 acetylation
Cellular Component
GO:0005634 nucleus
GO:0030914 STAGA complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0E3
PhosphoSite PhosphoSite-Q9H0E3
TrEMBL Q96DP1
UniProt Splice Variant
Entrez Gene 79595
UniGene Hs.32995
RefSeq NP_001139400
HUGO HGNC:29813
OMIM 609697
CCDS CCDS54397
HPRD 18015
IMGT
EMBL AC012306 AC118060 AK022823 AK055979 AL136833 AY220791 BC017453 BC117255 BC143898 CH471103
GenPept AAH17453 AAI17256 AAI43899 AAO63591 AAX88975 AAY14878 BAB14261 BAB71063 CAB66767 EAW95352

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca